NRAS Mutation Detection Kit
PCR
Real-time PCR Assays
16
Mutations
1%
1%
Sensitivity
Features
Selectable
- Pre-loaded and bulk formats are available.
1
- Pre-loaded and bulk formats are available.
Universal
- Compatible with tissue samples.
2
- Compatible with tissue samples.
Precise
- Top sensitivity of 1% mutant allele.
3
- Top sensitivity of 1% mutant allele.
Easy
- One-step procedure, results in 90 mins.
4
- One-step procedure, results in 90 mins.
Reliable
- Internal and external controls included.
5
- Internal and external controls included.
Product Description

NRAS Mutation Detection Kit

Detection of 16 mutations in NRAS codons 12, 13, 59, 61, 117 and 146

NRAS is a member of the RAS family of small GTPases and plays a central role in the MAPK signaling pathways. NRAS has been implicated in the pathogenesis of several cancers. NRAS mutations are particularly common in melanoma, hepatocellular carcinoma, myeloid leukemias, and thyroid carcinoma. In total, activating mutations in the NRAS genes occur in 13~25% of cutaneous melanomas, 1~6% of colorectal cancer and 1% of lung cancer, mainly in exons 2, 3 or 4.

The mutation status of NRAS gene is relevant to drug resistance of non-small cell lung cancer treated with tyrosine kinase inhibitors. As a result, NRAS mutations detection supplies evidence for targeted clinical therapy of tumor patients.

Technological Principles

The kit uses novel, patented primers and probes to detect mutations in a real-time PCR assay. The mutant DNA is amplified accurately by the specific primers, and detected by the novel probes. Highly Specific primers and probes, and a highly validated procedure based on Taq DNA polymerase contribute to outstanding assay sensitivity and selectivity.

Testing Procedure
Compatible Sample Types:FFPE samples
Compatible Real-time PCR Instrument
ABI 7500
Bio-Rad CFX96
LightCycler 480
Rotor-Gene 6000
Rotor-Gene Q
SLAN-96S
Stratagene Mx3000P™
Other Info.

To order, please contact sales@amoydx.com.

AmoyDx NRAS Mutations Detection Kits are available in the following size, minimum order of 8 tests.

Product Name

Type

 Size (test/kit)

 Storage

 Cat. No.

 NRAS Mutation Detection Kit

Bulk

 24T

 -20±5℃

 8.01.25001X024H

NRAS Mutation Detection Kit

Pre-loaded

8T

 -20±5℃

8.01.25001W008A
8.01.25001W008B
8.01.25001W008D
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